Comparative Serological Study for the Prevalence of Anti-MERS Coronavirus Antibodies in High- and Low-Risk Groups in Qatar
Identifieur interne : 000656 ( Main/Exploration ); précédent : 000655; suivant : 000657Comparative Serological Study for the Prevalence of Anti-MERS Coronavirus Antibodies in High- and Low-Risk Groups in Qatar
Auteurs : Reham A. Al Kahlout [Qatar] ; Gheyath K. Nasrallah [Qatar] ; Elmoubasher A. Farag [Qatar] ; Lingshu Wang [États-Unis] ; Erik Lattwein [Allemagne] ; Marcel A. Müller [Allemagne] ; Mohamed E. El Zowalaty [Afrique du Sud] ; Hamad E. Al Romaihi [Qatar] ; Barney S. Graham [États-Unis] ; Asmaa A. Al Thani [Qatar] ; Hadi M. Yassine [Qatar]Source :
- Journal of Immunology Research [ 2314-8861 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Faux positifs, Femelle, Groupes de population, Humains, Infections à coronavirus (immunologie), Jeune adulte, Mâle, Prévalence, Qatar, Risque, Réactions croisées, Sujet âgé, Sérologie.
- MESH :
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Infections à coronavirus.
- sang : Anticorps antiviraux.
- Adolescent, Adulte, Adulte d'âge moyen, Faux positifs, Femelle, Groupes de population, Humains, Jeune adulte, Mâle, Prévalence, Qatar, Risque, Réactions croisées, Sujet âgé, Sérologie.
- Wicri :
- geographic : Qatar.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic : Qatar.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- Adolescent, Adult, Aged, Cross Reactions, False Positive Reactions, Female, Humans, Male, Middle Aged, Population Groups, Prevalence, Risk, Serology, Young Adult.
Abstract
Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) could be asymptomatic or cause mild influenza-like illness. Therefore, the prevalence of MERS-CoV infections in the general population could be underestimated, which necessitates active surveillance to determine the epidemiological importance of asymptomatic cases. The aim of this study is to evaluate the performance of various serological assays and to estimate the seroprevalence of anti-MERS-CoV antibodies in high- and low-risk groups in Qatar. A total of 4858 samples were screened, including 4719 samples collected from healthy blood donors (BD) over a period of five years (2012-2016), 135 samples from baseline case contacts (CC) collected from individuals in close contact with three positive PCR-confirmed patients (CP), and four samples from MERS-CoV CP. Initial screening using anti-MERS-CoV IgG (IgG rS1-ELISA kit) revealed ten reactive samples from BD (10/4719, 0.21%), one from CC (1/135, 0.74%), and three from CP (3/4, 75%). Samples from CP but not from BD were also reactive by whole-virus anti-MERS-CoV IgG (
Url:
DOI: 10.1155/2019/1386740
PubMed: 30906787
PubMed Central: 6398027
Affiliations:
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Al Kahlout</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Nasrallah, Gheyath K" sort="Nasrallah, Gheyath K" uniqKey="Nasrallah G" first="Gheyath K." last="Nasrallah">Gheyath K. Nasrallah</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Biomedical Research Center, Qatar University, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Biomedical Research Center, Qatar University, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Farag, Elmoubasher A" sort="Farag, Elmoubasher A" uniqKey="Farag E" first="Elmoubasher A." last="Farag">Elmoubasher A. Farag</name><affiliation wicri:level="1"><nlm:aff id="I3">Communicable Diseases Control Programs, Public Health Department, Ministry of Public Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Communicable Diseases Control Programs, Public Health Department, Ministry of Public Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Lingshu" sort="Wang, Lingshu" uniqKey="Wang L" first="Lingshu" last="Wang">Lingshu Wang</name><affiliation wicri:level="2"><nlm:aff id="I4">Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lattwein, Erik" sort="Lattwein, Erik" uniqKey="Lattwein E" first="Erik" last="Lattwein">Erik Lattwein</name><affiliation wicri:level="1"><nlm:aff id="I5">Euroimmun AG, Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Euroimmun AG, Luebeck</wicri:regionArea><wicri:noRegion>Luebeck</wicri:noRegion><wicri:noRegion>Luebeck</wicri:noRegion><wicri:noRegion>Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A." last="Müller">Marcel A. Müller</name><affiliation wicri:level="3"><nlm:aff id="I6">Institute of Virology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="El Zowalaty, Mohamed E" sort="El Zowalaty, Mohamed E" uniqKey="El Zowalaty M" first="Mohamed E." last="El Zowalaty">Mohamed E. El Zowalaty</name><affiliation wicri:level="1"><nlm:aff id="I7">Virology and Microbiology Research Laboratory, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Virology and Microbiology Research Laboratory, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000</wicri:regionArea><wicri:noRegion>Durban 4000</wicri:noRegion></affiliation></author><author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E." last="Al Romaihi">Hamad E. Al Romaihi</name><affiliation wicri:level="1"><nlm:aff id="I3">Communicable Diseases Control Programs, Public Health Department, Ministry of Public Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Communicable Diseases Control Programs, Public Health Department, Ministry of Public Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Graham, Barney S" sort="Graham, Barney S" uniqKey="Graham B" first="Barney S." last="Graham">Barney S. Graham</name><affiliation wicri:level="2"><nlm:aff id="I4">Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Al Thani, Asmaa A" sort="Al Thani, Asmaa A" uniqKey="Al Thani A" first="Asmaa A." last="Al Thani">Asmaa A. Al Thani</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Biomedical Research Center, Qatar University, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Biomedical Research Center, Qatar University, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Yassine, Hadi M" sort="Yassine, Hadi M" uniqKey="Yassine H" first="Hadi M." last="Yassine">Hadi M. Yassine</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Biomedical Research Center, Qatar University, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Biomedical Research Center, Qatar University, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Immunology Research</title><idno type="ISSN">2314-8861</idno><idno type="eISSN">2314-7156</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antibodies, Viral (blood)</term><term>Coronavirus Infections (immunology)</term><term>Cross Reactions</term><term>False Positive Reactions</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Population Groups</term><term>Prevalence</term><term>Qatar</term><term>Risk</term><term>Serology</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Faux positifs</term><term>Femelle</term><term>Groupes de population</term><term>Humains</term><term>Infections à coronavirus (immunologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Prévalence</term><term>Qatar</term><term>Risque</term><term>Réactions croisées</term><term>Sujet âgé</term><term>Sérologie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Qatar</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Cross Reactions</term><term>False Positive Reactions</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Population Groups</term><term>Prevalence</term><term>Risk</term><term>Serology</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Faux positifs</term><term>Femelle</term><term>Groupes de population</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Prévalence</term><term>Qatar</term><term>Risque</term><term>Réactions croisées</term><term>Sujet âgé</term><term>Sérologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Qatar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) could be asymptomatic or cause mild influenza-like illness. Therefore, the prevalence of MERS-CoV infections in the general population could be underestimated, which necessitates active surveillance to determine the epidemiological importance of asymptomatic cases. The aim of this study is to evaluate the performance of various serological assays and to estimate the seroprevalence of anti-MERS-CoV antibodies in high- and low-risk groups in Qatar. A total of 4858 samples were screened, including 4719 samples collected from healthy blood donors (BD) over a period of five years (2012-2016), 135 samples from baseline case contacts (CC) collected from individuals in close contact with three positive PCR-confirmed patients (CP), and four samples from MERS-CoV CP. Initial screening using anti-MERS-CoV IgG (IgG rS1-ELISA kit) revealed ten reactive samples from BD (10/4719, 0.21%), one from CC (1/135, 0.74%), and three from CP (3/4, 75%). Samples from CP but not from BD were also reactive by whole-virus anti-MERS-CoV IgG (<italic>n</italic> = 3/4) and IgM (<italic>n</italic> = 1/4) indirect immunefluorescent tests (IIFT) and pseudoparticle neutralization test (ppNT). The reactive sample from CC was also confirmed by ppNT. Surprisingly, one out of thirteen (7.7%) randomly selected IgG rS1-ELISA-negative BD samples from the initial screening was reactive by the IgM-IIFT (but not by the IgG-IIFT) and was subsequently confirmed by ppNT. All IgG rS1-ELISA-reactive samples from BD exhibited considerable reactivity to the four circulating human coronaviruses (HKU1, OC43, 229E, and NL63). Cross-reactivity with SARS was only reported for samples from CP using IgG and IgM-IIFT. In conclusion, we report a low prevalence of anti-MERS antibodies in the general population, which coincides with the low number of all reported cases by the time of our study (2017) in Qatar (<italic>n</italic> = 21). The false-positive results and the observed cross-reactivity between MERS-CoV and other circulating human coronavirus necessitate more detailed evaluation of available serological assays.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M. G. Hemida</name></author><author><name sortKey="Alnaeem, A" uniqKey="Alnaeem A">A. Alnaeem</name></author><author><name sortKey="Chu, D K W" uniqKey="Chu D">D. K. W. Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V. S. Raj</name></author><author><name sortKey="Farag, E A" uniqKey="Farag E">E. A. Farag</name></author><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C. B. Reusken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B. L. 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Al Thani</name><name sortKey="Al Thani, Asmaa A" sort="Al Thani, Asmaa A" uniqKey="Al Thani A" first="Asmaa A." last="Al Thani">Asmaa A. Al Thani</name><name sortKey="Farag, Elmoubasher A" sort="Farag, Elmoubasher A" uniqKey="Farag E" first="Elmoubasher A." last="Farag">Elmoubasher A. Farag</name><name sortKey="Nasrallah, Gheyath K" sort="Nasrallah, Gheyath K" uniqKey="Nasrallah G" first="Gheyath K." last="Nasrallah">Gheyath K. Nasrallah</name><name sortKey="Nasrallah, Gheyath K" sort="Nasrallah, Gheyath K" uniqKey="Nasrallah G" first="Gheyath K." last="Nasrallah">Gheyath K. Nasrallah</name><name sortKey="Yassine, Hadi M" sort="Yassine, Hadi M" uniqKey="Yassine H" first="Hadi M." last="Yassine">Hadi M. Yassine</name><name sortKey="Yassine, Hadi M" sort="Yassine, Hadi M" uniqKey="Yassine H" first="Hadi M." last="Yassine">Hadi M. Yassine</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Wang, Lingshu" sort="Wang, Lingshu" uniqKey="Wang L" first="Lingshu" last="Wang">Lingshu Wang</name></region><name sortKey="Graham, Barney S" sort="Graham, Barney S" uniqKey="Graham B" first="Barney S." last="Graham">Barney S. Graham</name></country><country name="Allemagne"><noRegion><name sortKey="Lattwein, Erik" sort="Lattwein, Erik" uniqKey="Lattwein E" first="Erik" last="Lattwein">Erik Lattwein</name></noRegion><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A." last="Müller">Marcel A. Müller</name></country><country name="Afrique du Sud"><noRegion><name sortKey="El Zowalaty, Mohamed E" sort="El Zowalaty, Mohamed E" uniqKey="El Zowalaty M" first="Mohamed E." last="El Zowalaty">Mohamed E. El Zowalaty</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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